Start by patting the fish fillets dry with a paper towel and seasoning them with salt, pepper, and garlic powder.
Set up a breading station: place the flour in one bowl, the beaten eggs in another, and the breadcrumbs in a third bowl.
Dip each fillet first in the flour, then the eggs, and finally coat with breadcrumbs. Ensure each piece is evenly covered.
Heat the vegetable oil in a large skillet over medium-high heat. Once hot, carefully add the breaded fillets.
Fry each fillet for about 3-4 minutes per side or until golden brown and cooked through. Transfer to a paper towel-lined plate to drain excess oil.
While the fish is frying, lightly toast the hamburger buns in a separate skillet or under a broiler.
To assemble, place a slice of American cheese on the bottom half of each bun, add the crispy fish fillet, and spread a generous amount of tartar sauce on the top bun.
Serve immediately with your favorite sides.
